Jobs - Join our Team

Scientist I - Process Development

​

Position Overview: 

As a Scientist I in the Process & Analytical Development (P&AD) team, you will be responsible for providing technical expertise in the creation and optimization of manufacturing processes crucial for the production of cutting-edge cell therapies for liver disease. Collaborating closely with multidisciplinary teams, you will contribute to the design, execution, and improvement of the final drug product (the ReLiver®), ensuring process scalability, reproducibility, and regulatory compliance. This role offers a unique opportunity to make a significant impact on patient care while developing your skills in a dynamic and collaborative environment.

 

Key Responsibilities: 

 

• Conceive, design, and execute experiments to support the development of cell-based drug substances and combination (device) products throughout the product lifecycle - from early development through clinical phases.

• Apply design of experiments (DoE) principles, perform statistical data analyses, and interpret results to inform and drive process optimization and improvements.

• Identify critical process parameters (CPPs) and develop control strategies to ensure drug substance consistency and alignment with the quality target product profile (QTPP).

• Develop and optimize robust, scalable platforms and processes to support product advancement from research through clinical manufacturing.

• Scale up processes using advanced bioreactor systems (ranging from 100 mL to 50 L), ensuring the preservation of product quality and critical performance attributes.

• Enhance existing analytical methods and establish novel techniques to evaluate product quality and performance at various stages of development.

• Collaborate with cross-functional teams—including Analytical Development, Biomaterials Development, and Preclinical—to produce materials for in vitro and in vivo studies.

• Provide technical leadership and innovative problem-solving to address complex development challenges.

• Maintain detailed, accurate documentation of experimental protocols, results, and conclusions in compliance with internal standards and regulatory requirements.

• Author and review standard operating procedures (SOPs) to support consistent and compliant operations.

• Foster a collaborative team culture by sharing technical insights and providing mentorship to junior team members.
   

Qualifications: 

• Ph.D. or Master’s degree in Biochemical Engineering, Cell Biology, Biotechnology, or a related field, with 4+ years of relevant industry experience.

• Required: Demonstrated expertise in induced pluripotent stem cell (iPSC) culture and differentiation. The ideal candidate will have hands-on experience with: 
  - Suspension-based differentiation methods   
  - Differentiation into multiple cell lineages   
  - Industry-level development of differentiated cell therapy products

• Required: Proficiency in key analytical techniques, including flow cytometry, qPCR, ELISA, and other relevant cell-based assays.

• Experience in bioprocessing, with demonstrated skills in one or more of the following areas:         
  - Bioreactor operation and scale-up
  - Cell concentration and separation techniques    
  - Perfusion systems   
  - Cryopreservation methods

• Strong statistical acumen, with a proven ability to apply data-driven and statistical approaches to solve complex problems and clearly communicate results.

• Track record of independently planning, executing, and analyzing experiments, contributing meaningfully to both hands-on laboratory work and strategic experimental design.

• Experience working on cross-functional, multidisciplinary teams, with the ability to collaborate effectively in fast-paced, dynamic environments and adapt to shifting priorities.

• Excellent critical thinking and problem-solving skills, with the ability to analyze complex data sets, identify trends, and propose actionable solutions.

• Familiarity with Design of Experiments (DoE) and Quality by Design (QbD) methodologies.

• Exceptional written and verbal communication skills, with the ability to clearly present findings, influence decision-making, and engage in productive team discussions.

 

Why Morphocell: 
 

• Join a dynamic team of professionals committed to pushing the boundaries of cell therapy. 

•  Contribute to groundbreaking advancements in the field of biotechnology. 

• Opportunity for personal and professional growth in a fast-paced and collaborative environment. 

• Competitive compensation package.

• Group medical and dental insurance.

• RRSP matching contribution.

• Commuting travel benefits.
   

If you're a driven scientist with a passion for Process development in the realm of cell therapy, we invite you to apply for the Scientist I role. Join us in our mission to redefine healthcare through innovative cell therapies. 
 

To apply, please submit your resume and cover letter to: career@morphocell.com .